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Category: Epidemiology, U.S. National Library of Medicine

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The Threat   Throughout the last three thousand years, smallpox has shadowed civilization. A viral infection, the disease spread along trade routes, emerging first in Africa, Asia and Europe and reaching the Americas in the sixteenth century. Because smallpox requires a human host to survive it tended to smolder in densely populated areas, erupting in a full-blown epidemic every ten years or so. Wherever it appeared, the legacy of smallpox was death, blindness, sterility and scarring.     While some medical practitioners claimed to cure smallpox, most medical traditions focused on prevention.

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History of Medicine Epidemic cholera is an acute, painful, and often fatal disease which ravaged nearly the entire world during several severe outbreaks over the course of the 19th century. It is a diarrheal disease which can cause death by dehydration to an untreated patient in a matter of hours and is extremely contagious in communities without adequate, modern sanitation, as most of the world was in 1817 when it first left India. News of its spread and impending approach often sent panic into entire nations, and health professionals were largely at a loss as to how to treat or prevent it until modern epidemiological and laboratory techniques were developed later in the century.

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