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Introduction In 1999, inspired by the remarkable success of the Human Genome Project, the OSU Libraries Special Collections launched an ambitious undertaking that seeks to closely-document virtually every day of Linus and Ava Helen Pauling's lives. The result is Linus Pauling Day-by-Day, a constantly-expanding resource that provides in-depth description for a substantial portion of the half-million item Ava Helen and Linus Pauling Papers. This huge amount of data is presented in easy-to-use calendar form. Index pages created for each year of the Day-by-Day calendar provide an overview of the major events in the Paulings' lives, a full accounting of their travel and snapshots from their various adventures at home and abroad.